The feasibility of reversing human aging within a matter of decades has traditionally been dismissed by all professional biogerontologists, on the grounds that not only is aging still poorly understood, but also many of those aspects that we do understand are not reversible by any current or foreseeable therapeutic regimen. This broad consensus has recently been challenged by the publication, by five respected experimentalists in diverse subfields of biogerontology together with three of the present authors, of an article (Ann NY (...) Acad Sci 959, 452–462) whose conclusion was that all the key components of mammalian aging are indeed amenable to substantial reversal (not merely retardation) in mice, with technology that has a reasonable prospect of being developed within about a decade. Translation of that panel of interventions to humans who are already alive, within a few decades thereafter, was deemed potentially feasible (though it was not claimed to be likely). If the prospect of controlling human aging within the foreseeable future cannot be categorically rejected, then it becomes a matter of personal significance to most people presently alive. Consequently, we suggest that serious public debate on this subject is now warranted, and we survey here several of the biological, social and political issues relating to it. BioEssays 24:667–676, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

After having defined the KARO logic for specifying intelligent agents in earlier work we now turn to the question how to realise agents specified in the KARO framework. To this end we look at agent programming languages that we have defined, and investigate how programs in these languages can be linked to the KARO logic.

On the ethics of extending human life: healthy people have a right to carry on livingHumanity has long demonstrated a paradoxical ambivalence concerning the extension of a healthy human lifespan. Modest health extension has been universally sought, whereas extreme health extension has been regarded as a snare and delusion—a dream beyond all others at first blush, but actually something we are better off without. The prevailing pace of biotechnological progress is bringing ever closer the day when humanity will be able (...) to act on the latter view by rejecting a clear and present opportunity for much longer healthy lives. Indeed, some biogerontologists contend that that day has already arrived, to the extent that our hesitation in embarking on a vigorous “war on ageing” is already delaying the point at which a cure for ageing will be developed. Here I consider whether our present caution concerning the wisdom of truly curing ageing is likely to survive the increased scrutiny that it will receive in coming years as a result of these technical advances. I conclude that it will not, because of its irreconcilability with values that are more deeply held by the large majority of humanity than any values that argue against the quest for a cure. I further conclude that all the major current reasons given for not curing ageing are mere crutches to help us cope with the immutability of ageing that we have been brought up to accept. Our failure to set aside such irrationality is already shortening potential longevity—quite probably of those already alive today—to a staggering degree. Once we realise this, our determination to consign human ageing to history will be second …. (shrink)

In this volume specialists of medieval music and philosophy put the medieval 'musica' into the context of ideas and institutions in which it existed. The significance of 'musica' cannot be understood from a modern point of view since 'music' does not match the medieval 'musica'.

The feasibility of reversing human aging within a matter of decades has traditionally been dismissed by all professional biogerontologists, on the grounds that not only is aging still poorly understood, but also many of those aspects that we do understand are not reversible by any current or foreseeable therapeutic regimen. This broad consensus has recently been challenged by the publication, by five respected experimentalists in diverse subfields of biogerontology together with three of the present authors, of an article (Ann NY (...) Acad Sci 959, 452–462) whose conclusion was that all the key components of mammalian aging are indeed amenable to substantial reversal (not merely retardation) in mice, with technology that has a reasonable prospect of being developed within about a decade. Translation of that panel of interventions to humans who are already alive, within a few decades thereafter, was deemed potentially feasible (though it was not claimed to be likely). If the prospect of controlling human aging within the foreseeable future cannot be categorically rejected, then it becomes a matter of personal significance to most people presently alive. Consequently, we suggest that serious public debate on this subject is now warranted, and we survey here several of the biological, social and political issues relating to it. BioEssays 24:667–676, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Over recent years, evidence has been accumulating in favour of the free radical theory of aging, first proposed by Harman. Despite this, an understanding of the mechanism by which cells might succumb to the effects of free radicals has proved elusive. This paper proposes such a mechanism, based on a previously unexplored hypothesis for the proliferation of mutant mitochondrial DNA: that mitochondria with reduced respiratory function, due to a mutation or deletion affecting the respiratory chain, suffer less frequent lysosomal degradation, (...) because they inflict free radical damage more slowly on their own membranes. Once such a mutation occurs in a mitochondrion of a non‐dividing cell, therefore, mitochondria carrying it will rapidly populate that cell, thereby destroying the cell's respiratory capability. The accumulation of cells that have undergone this transition results in aging at the organismal level. The consistency of the hypothesis with known facts is discussed, and technically feasible tests are suggested, of both the proposed mechanism and its overall contribution to mammalian aging. (shrink)

According to familiar accounts, Rousseau held that humans are actuated by two distinct kinds of self love: amour de soi, a benign concern for one's self-preservation and well-being; and amour-propre, a malign concern to stand above other people, delighting in their despite. I argue that although amour-propre can (and often does) assume this malign form, this is not intrinsic to its character. The first and best rank among men that amour-propre directs us to claim for ourselves is that of occupying (...) 'man's estate'. This does not require, indeed it precludes, subjection of others. Amour-propre does not need suppression or circumscription if we are to live good lives; it rather requires direction to its proper end, not a delusive one. (shrink)

In 1996, the anthropologist Eduardo Viveiros de Castro chose a sentence by Gilles Deleuze as the epigraph for an article, published in the Brazilian journal Mana, on Amerindian perspectivism. (A modified version of the article appeared in English two years later, in the Journal of the Royal Anthropological Institute.) Since then, Deleuze's name has appeared often in works about perspectivism, but Chamois's new book is the first monograph to focus on perspectivism and Deleuze. Among the most important contributions of Chamois's (...) analysis is to draw our attention to a little-known passage in a course, “Truth and Time,” that Deleuze taught in 1983 (and that is available for listening online). In it, he criticizes the example of the cube used as a paradigm, at least since Edmund Husserl's day, to conceptualize what a perspective is. It is impossible to see all six faces of a cube at the same time; thus, to “intuit” the cube as a cube, we must add to our own perception of a profile of the cube more possible points of view on it. The problem with this example and description is that it takes for granted that the subject already knows what she needs to see (a cube).Inspired, however, by the process philosophy of Alfred North Whitehead, Deleuze holds that each perception is an invitation to other perceptions: “To perceive is to become capable of perceiving more and more things that were initially not perceived” (percevoir, c'est devenir apte à percevoir de plus en plus de choses qui d'abord n’étaient pas perçues). Deleuze contrasts the “spatial” or “frozen” notion of perspective to the “temporal perspective” that he seeks to emphasize: “It's time that acts as perspective” (C'est le temps qui agit comme perspective). The question, therefore, at the heart of Deleuze's perspectivism is how a perspective changes over time. Chamois goes through the early texts of Deleuze to show how the idea of the temporal perspective emerged from the concept of the structure Autrui. The “structure-Other” is best exemplified by someone else's emotive face—the frightened face of my friend, for instance. If I perceive that face while, say, I am laughing, another possible world would slip into my own: a frightening world penetrates my humorous one, and perhaps I should turn my head to see what danger may be en route. As in the case of the cube, my own limited perception is supplemented by others’ limited perceptions. The object of perception in this case, however, is not presupposed to be stable (the world is changing), and what I am about to see is not known in advance.But what, precisely, in the face of the other must I notice to become aware of the world she perceives? Deleuze does not explore that question in any detail, but Chamois reviews recent anthropological and psychological research that supplies some elements of a response. To confront the writings of Deleuze with relevant scientific data is fruitful. I must admit, though, that I was a bit embarrassed by the framing of the discussion: Chamois presents Deleuze's concepts as hypotheses demanding verification that they are “corroborated by the facts.” For Deleuze, concepts are inseparable from percepts and affects; as opposed to a hypothesis, a concept is true not because it correlates to a set of relevant facts but because it helps us to perceive other aspects of the world (percept) and induces us to act better (affect). Thus, the minute and rewarding analysis of Chamois should be complemented with an assessment of what we learn to focus on and of how we change our actions thanks to the perspectivism of Deleuze—in contrast to other forms of perspectivism (or indeed to other cosmologies). (shrink)

According to familiar accounts, Rousseau held that humans are actuated by two distinct kinds of self love: amour de soi, a benign concern for one's self-preservation and well-being; and amour-propre, a malign concern to stand above other people, delighting in their despite. I argue that although amour-propre can assume this malign form, this is not intrinsic to its character. The first and best rank among men that amour-propre directs us to claim for ourselves is that of occupying 'man's estate'. This (...) does not require, indeed it precludes, subjection of others. Amour-propre does not need suppression or circumscription if we are to live good lives; it rather requires direction to its proper end, not a delusive one. (shrink)

A fundamental fact about human minds is that they are never truly alone: all minds are steeped in situated interaction. That social interaction matters is recognized by any experimentalist who seeks to exclude its influence by studying individuals in isolation. On this view, interaction complicates cognition. Here, we explore the more radical stance that interaction co-constitutes cognition: that we benefit from looking beyond single minds toward cognition as a process involving interacting minds. All around the cognitive sciences, there are approaches (...) that put interaction center stage. Their diverse and pluralistic origins may obscure the fact that collectively, they harbor insights and methods that can respecify foundational assumptions and fuel novel interdisciplinary work. What might the cognitive sciences gain from stronger interactional foundations? This represents, we believe, one of the key questions for the future. Writing as a transdisciplinary collective assembled from across the classic cognitive science hexagon and beyond, we highlight the opportunity for a figure-ground reversal that puts interaction at the heart of cognition. The interactive stance is a way of seeing that deserves to be a key part of the conceptual toolkit of cognitive scientists. (shrink)

All we know of this law is to be found in Cicero's Pro Cluentio. Elsewhere we have only one passing reference to it. However, this speech seems to give us the main clause of the bill as it appeared after incorporation in the Lex Cornelia de sicariis el veneficis: ‘Qui tribunus militum legionibus quattuor primis quive quaestor, tribunus plebis’ —deinceps omnes magistratus nominavit—‘quive in senatu sententiam dixit dixerit, qui eorum coiit, coierit, convenit, convenerit quo quis iudicio publico condemnaretur de eius (...) capite quaerito. (shrink)